Enaminouraciles as Precursors for Synthesis of Pyrimido[4,5-a]pyrimidine- 2,4-diones
نویسنده
چکیده
W. S. H am am a Chemistry D epartm ent, Faculty of Science, M ansoura University, M ansoura, Egypt R eprint requests to Dr. W. S. H am am a. E-mail: Sinfac@ mum.mans.eun.eg Z. Naturforsch. 55b, 443-447 (2000); received January 25, 2000 6-Am inouracil, M annich Reaction, Pyrimido[4,5-d]pyrim idine The reaction of 6-am inouracil 1 with form aldehyde and secondary amines in ethanol at room tem perature gave the corresponding 5-alkylam inom ethyl derivatives (2a-c) and bis(4pyrim idyl)m ethane (4). Also, M annich reaction with prim ary aliphatic and arom atic amines at room tem perature afforded pyrimido[4,5-rf]pyrimidine (5 and 6). Treatm ent of 1 with o-phenylenediam ine through transam ination gave com pound 7 which cyclized through intram olecular M annich reaction with formalin to yield pyrimido[4,5-el[l,4]diazepine (8).
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Facile one-pot synthesis of pyrimido[4,5-d]pyrimidine-2,4-diones in Ionic Liquid and study of their antibacterial activities
A simple, novel, efficient and three-component procedure for the synthesis of pyrimido[4,5-d]pyrimidine-2,4-dione derivatives by the reaction of 6-amino-1,3-dimethyluracil, aldehyde and 2-benzylisothiourea hydrochloride promoted by ionic liquid 1-butyl-3-methylimidazolium bromide ([BMIm]Br) under solvent-free conditions is reported. The presented method is benefited from operational simplicity...
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A simple, novel, efficient and three-component procedure for the synthesis of pyrimido[4,5-d]pyrimidine-2,4-dione derivatives by the reaction of 6-amino-1,3-dimethyluracil, aldehyde and 2-benzylisothiourea hydrochloride promoted by ionic liquid 1-butyl-3-methylimidazolium bromide ([BMIm]Br) under solvent-free conditions is reported. The presented method is benefited from operational simplicity...
متن کاملFacile one-pot synthesis of pyrimido[4,5-d]pyrimidine-2,4-diones in Ionic Liquid and study of their antibacterial activities
A simple, novel, efficient and three-component procedure for the synthesis of pyrimido[4,5-d]pyrimidine-2,4-dione derivatives by the reaction of 6-amino-1,3-dimethyluracil, aldehyde and 2-benzylisothiourea hydrochloride promoted by ionic liquid 1-butyl-3-methylimidazolium bromide ([BMIm]Br) under solvent-free conditions is reported. The presented method is benefited from operational simplicity,...
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